A HYPOTHESIS FOR THE STRUCTURE OF THE CARBOHYDRATE RECOGNITION SITE ON fl - D - N - ACETYLHEXOSAMINIDASE
نویسنده
چکیده
I-cell disease (mucolipidosis II) is presented as a model for endoand exo-cytosis phenomena in man. A hypothesis is presented for the structure of the carbohydrate recognition site on fibroblast-derived fJ-D-N-acetylhexosaminidase that may extend to the other affected hydrolases and that is responsible for specific uptake of the enzyme by fibroblasts. The proposed neuraminidase deficiency in I-cell disease is discussed in the light of its significance in influencing the final sugar sequence in the carbohydrate structure of the recognition site.
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تاریخ انتشار 2005